Table 3.
Odds ratios for BE and BE with dysplasia associated with smoking, obesity and NSAIDs
| Controls | BE | BE with dysplasia | |||||
|---|---|---|---|---|---|---|---|
| Crude | Adjusted | Crude | Adjusted | ||||
| Exposure | N=261 | N=117 | OR (95% CI)* | OR (95% CI)† | N=50 | OR (95% CI)* | OR (95% CI)† |
| Cigarette smoking intensity (pack-years) | |||||||
| None | 46% | 27% | 1.0 | 1.0 | 18% | 1.0 | 1.0 |
| 25 or less | 28% | 44% | 2.5 (1.5-4.4) | 3.1 (1.6-6.0) | 44% | 3.7 (1.6-8.5) | 3.8 (1.4-10.3) |
| More than 25 | 26% | 29% | 2.1 (1.1-3.8) | 2.2 (1.1-4.5) | 38% | 2.9 (1.2-6.9) | 3.3 (1.2-9.5) |
| Maximum BMI (kg/m2) | |||||||
| 18.5 – 24.9 | 25% | 22% | 1.0 | 1.0 | 12% | 1.0 | 1.0 |
| 25 - 29.9 | 46% | 36% | 1.0 (0.5-1.7) | 0.9 (0.5-1.8) | 45% | 1.7 (0.6-4.4) | 1.3 (0.5-3.9) |
| ≥ 30 | 28% | 42% | 1.7 (0.9-3.2) | 1.5 (0.7-3.1) | 43% | 2.9 (1.1-7.7) | 2.1 (0.7-6.4) |
| Aspirin/NSAIDS (frequency of use in past 5 years) | |||||||
| Never | 23% | 27% | 1.0 | 1.0 | 24% | 1.0 | 1.0 |
| Occasionally | 32% | 32% | 0.7 (0.4-1.4) | 0.8 (0.4-1.5) | 36% | 1.0 (0.4-2.2) | 0.9 (0.4-2.4) |
| <2-3/month | 12% | 11% | 0.6 (0.3-1.3) | 0.8 (0.3-1.9) | 2% | 0.1 (0.0-1.1) | 0.1 (0.0-1.0) |
| ≥ 1/week | 34% | 29% | 0.8 (0.4-1.5) | 0.6 (0.3-1.3) | 38% | 1.1 (0.5-2.6) | 0.8 (0.3-2.1) |
| Acetominophen (frequency of use in past 5 years) | |||||||
| Never | 17% | 13% | 1.0 | 1.0 | 6% | 1.0 | 1.0 |
| Occasionally | 51% | 43% | 0.9 (0.4-1.7) | 0.7 (0.3-1.5) | 48% | 2.4 (0.7-8.3) | 2.6 (0.6-11.4) |
| <2-3/month | 19% | 21% | 0.9 (0.4-2.1) | 1.0 (0.4-2.3) | 20% | 3.0 (0.7-11.9) | 4.1 (0.8-20.8) |
| ≥ 1/week | 14% | 24% | 1.9 (0.8-4.1) | 1.3 (0.5-3.1) | 26% | 5.0 (1.3-19.3) | 3.1 (0.6-15.1) |
*
Odds ratio and 95% confidence intervals adjusted for exact age in years and sex
†
Odds ratio and 95% confidence intervals adjusted for exact age in years, sex, frequency of acid reflux symptoms in current age group, BMI (continuous), pack years smoked (continuous), NSAID use