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. 2006 Jun 22;116(7):1886–1901. doi: 10.1172/JCI27123

Figure 4. Phenotypic characteristics of control (open symbols; white bars) and PPKO (filled symbols; black bars) female mice under different dietary conditions with respect to energy homeostasis.

Figure 4

(A)Average body weight of ND- (triangles) and HFD-fed (circles) female mice (n = 6–81). (B)Outward appearance of 2 control and 2 PPKO female mice of the same litter at the age of 20 weeks (17 weeks of HFD feeding). (C)Exemplary demonstration of parametrial fat pads in situ (upper panel; black diamonds) and ex situ (lower panel; white diamonds) of control and PPKO females at the age of 20 weeks. (D)Absolute parametrial fat pad weights of female control and PPKO mice on ND and HFD (n = 3–17) and relative (corrected for body weight) parametrial fat pad weights of female HFD-fed control and PPKO mice. (E)Serum leptin levels of female control and PPKO mice on ND and HFD (n = 4–30). (F)Daily caloric intake of female control and PPKO mice on HFD at the age of 10–13 weeks (n = 4–6). (G)Oxygen consumption of female mice on HFD at the age of 12 weeks (n = 7–8). (H)Locomotor activity of female mice on HFD at the age of 12 weeks (n = 7–8). Unless otherwise indicated, data were collected at 20 weeks of age. Values are mean ± SEM. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 versus control.