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Schematic view of the effects of p42 MAPK on Cdc2 activation. (A) p42 MAPK can directly phosphorylate and activate Wee1 (this work) and, via the intermediacy of Rsk, inactivate Myt1 (Palmer et al., 1998). (B) The postfertilization cell cycles (the conclusion of meiosis II and early embryogenesis) are shown. The present work indicates that the prolonged period of p42 MAPK activation before the first embryonic cell cycle contributes to the presence of a G2 phase in that cycle.
