Abstract
When the heart-lung preparation is made from a dog treated with reserpine, catechol amines such as noradrenaline and isoprenaline have a greater effect on the rate of the heart than they have in a preparation from a normal dog. Other sympathomimetic amines such as tyramine and ephedrine, on the other hand, are found to have lost their action. Since treatment with reserpine has been shown to cause the store of noradrenaline in the heart to disappear, and the infusion of noradrenaline into the preparation made from a reserpine-treated animal restores the action of tyramine, it is concluded that substances like tyramine and ephedrine normally act by liberating noradrenaline from the store, and do not act directly. Cocaine, like reserpine, increases the effect of noradrenaline and decreases the effect of tyramine on the heart rate; it appears to block the release of noradrenaline from the store in the heart.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AXELROD J. Studies on sympathomimetic amines. I. The biotransformation and physiological disposition of l-ephedrine and l-norephedrine. J Pharmacol Exp Ther. 1953 Sep;109(1):62–73. [PubMed] [Google Scholar]
- KRAYER O., OURISSON P. Studies on veratrum alkaloids: XIX. The action of veratramine upon cardioacceleration caused by ephedrine, tyramine, phenylephrine and isopropylarterenol. J Pharmacol Exp Ther. 1954 Nov;112(3):341–355. [PubMed] [Google Scholar]
- KRAYER O. Studies on veratrum alkaloids. XII. A quantitative comparison of the antiaccelerator cardiac action of veratramine, veratrosine, jervine and pseudo-jervine. J Pharmacol Exp Ther. 1950 Apr;98(41):427–436. [PubMed] [Google Scholar]
- PAASONEN M. K., KRAYER O. The release of norepinephrine from the mammalian heart by reserpine. J Pharmacol Exp Ther. 1958 Jun;123(2):153–160. [PubMed] [Google Scholar]
- REINERT H. Zum Wirkungsmechanismus der Amphetamine. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;232(1):327–328. [PubMed] [Google Scholar]
- VON EULER U. S. The catechol amine content of various organs of the cat after injections and infusions of adrenaline and Noradrenaline. Circ Res. 1956 Nov;4(6):647–652. doi: 10.1161/01.res.4.6.647. [DOI] [PubMed] [Google Scholar]