Table 2.
Intention to treat analysis. Predictors of primary outcome (all cause mortality, acute myocardial infarction, unstable angina, and congestive heart failure) among patients with diabetes undergoing non-cardiac surgery
| Hazard ratio (95% CI) | P value | |
|---|---|---|
|
Univariate analyses |
||
| Metoprolol |
1.06 (0.80 to 1.41) |
0.66 |
| Age (>65 or ≤65 years) |
2.62 (1.91 to 3.58) |
<0.001 |
| Sex |
1.25 (0.93 to 1.68) |
0.13 |
| Coronary artery disease |
1.60 (1.18 to 2.17) |
0.002 |
| Malignant disease |
1.90 (1.40 to 2.59) |
<0.001 |
| Expected surgical stress |
1.31 (0.98 to 1.77) |
0.07 |
| Centre |
Not shown† |
0.08 |
|
Multivariate analyses* |
||
| Metoprolol |
1.05 (0.79 to 1.40) |
0.53 |
| Age (>65 or ≤65 years) |
2.48 (1.79 to 3.43) |
<0.001 |
| Sex |
1.17 (0.86 to 1.57) |
0.31 |
| Coronary artery disease |
1.35 (0.99 to 1.85) |
0.056 |
| Malignant disease |
1.55 (1.09 to 2.19) |
0.014 |
| Expected surgical stress |
1.02 (0.39 to 1.41) |
0.89 |
| Centre |
Not shown† |
0.14 |
|
Multivariate analyses including preoperative insulin treatment |
||
| Metoprolol |
1.07 (0.80 to 1.42) |
0.65 |
| Age (>65 or ≤65 years) |
2.56 (1.85 to 3.55) |
<0.001 |
| Sex |
1.17 (0.87 to 1.59) |
0.30 |
| Coronary artery disease |
1.38 (1.01 to 1.88) |
0.04 |
| Malignant disease |
1.57 (1.10 to 2.22) |
0.01 |
| Expected surgical stress |
1.04 (0.75 to 1.44) |
0.83 |
| Centre |
Not shown† |
0.11 |
| Preoperative insulin treatment | 1.36 (1.02 to 1.83) | 0.04 |
*
Based on a Cox proportional hazards model including all variables used for stratification at randomisation and trial drug as mandatory covariates.
‡
Data not reported from all 13 centres.