Table 4.
Daily dose of metoprolol (M) and placebo (P). Figures are number (percentage) of patients
|
Variable |
Day 2* | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | P | M | P | M | P | M | P | M | P | M | P | M | P | |
| Full dose |
294 (64) |
357 (78) |
311 (67) |
358 (78) |
235 (51) |
304 (66) |
192 (42) |
267 (58) |
167 (36) |
231 (50) |
145 (31) |
202 (44) |
123 (27) |
173 (38) |
| Half dose† |
122 (26) |
70 (15) |
65 (14) |
32 (7) |
58 (13) |
31 (7) |
57 (12) |
14 (3) |
46 (10) |
17 (4) |
34 (7) |
15 (3) |
24 (5) |
13 (3) |
| Not treated‡ | 46 (10) | 32 (7) | 86 (19) | 69 (15) | 169 (37) | 124 (27) | 213 (46) | 178 (39) | 249 (54) | 211 (46) | 283 (61) | 283 (53) | 315 (68) | 273 (59) |
*
Day 1 defined as day before surgery. Day 2 is day of surgery before induction of anaesthesia. Days 3-8 are postoperative days.
†
Because of heart rate between 55-65 beats per minute and systolic blood pressure ≥100 mm Hg.26
‡
Because of contraindications (heart rate <55 beats per minute or systolic blood pressure <100 mm Hg), discharge, or death.26