Table 5.
No of reported serious adverse events
| Metoprolol | Placebo | |
|---|---|---|
| Cardiovascular: |
||
| Myocardial infarction |
3 |
4 |
| Myocardial ischaemia |
0 |
1 |
| Congestive heart failure |
2 |
1* |
| Atrial fibrillation |
6 |
2 |
| Atrioventricular dissociation |
2 |
1* |
| Bradycardia |
4 |
0 |
| Hypotension |
2 |
1 |
| Cardiac arrest |
2 |
1 |
| Sudden death |
2 |
3 |
| Pulmonary: |
||
| Respiratory failure |
1 |
0 |
| Pneumonia |
1 |
1 |
| Gastrointestinal: |
||
| Ileus |
1 |
1 |
| Anastomosis leakage |
1 |
0 |
| Gastrointestinal haemorrhage |
2 |
1 |
| Perforated intestine |
0 |
1 |
| Peritonitis |
1 |
0 |
| Necrotising fasciitis |
0 |
1 |
| Reoperation |
0 |
1 |
| Cerebral: |
||
| Stroke |
2 |
0 |
| Psychosis |
1 |
0 |
| Delirium |
0 |
2 |
| Dizziness |
0 |
1 |
| Intoxication |
0 |
1 |
| Metabolic: |
||
| Ketoacidosis |
1 |
0 |
| Nephrological: |
||
| Acute tubular interstitial nephropathy |
1 |
1 |
| Extremities: |
||
| Amputation |
0 |
1 |
| Systemic: |
||
| Allergic reaction |
1 |
0 |
| All | 36† | 26† |
*
One patient having two reported serious adverse events.
†
No significant difference between metoprolol and placebo group, P=0.2.