Table 6.
Means of heart rates and arterial pressures
|
Day* |
Mean (SD, range) heart rate (beats/min) |
Mean (SD, range) arterial pressure (mm Hg) |
||
|---|---|---|---|---|
| Metoprolol | Placebo | Metoprolol | Placebo | |
| 1 |
78 (12, 47-120) |
79 (12, 50-128)† |
103 (14, 58-150) |
104 (14, 61-145)† |
| 2 |
72 (12, 40-122) |
77 (13, 50-128)‡ |
99 (14, 58-147) |
102 (14, 63-145)§ |
| 3 |
74 (12, 40-120) |
83 (14, 48-132)‡ |
91 (16, 56-139) |
94 (16, 50-149)§ |
| 4 |
75 (12, 49-120) |
84 (14, 52-120)‡ |
92 (15, 51-149) |
95 (15, 47-132)§ |
| 5 |
75 (13, 44-124) |
84 (14, 50-136)‡ |
92 (14, 58-140) |
96 (14, 58-142)§ |
| 6 |
75 (14, 44-135) |
82 (13, 46-124)‡ |
93 (14, 55-144) |
96 (14, 63-148)§ |
| 7 |
75 (12, 50-112) |
83 (13, 47-124)‡ |
94 (14, 53-127) |
97 (15, 50-167)§ |
| 8 | 76 (14, 44-131) | 83 (13, 52-123)‡ | 92 (14, 51-149) | 97 (15, 57-140)§ |
*
Day 1 is first day of study drug administration on day before surgery. Day 2 is day of surgery. Days 3-8 are six postoperative days. Values days 1-8 are from just before next dose of study drug was to be given.
†
P=0.7 at day 1 for comparison of mean heart rates and mean arterial pressures.
‡
P<0.001 at day 2-8 for comparison of mean heart rates.
§
P<0.02 at day 2-8 for comparison of means of mean arterial pressures.