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. Author manuscript; available in PMC: 2006 Jun 23.
Published in final edited form as: J Cardiovasc Electrophysiol. 2006 May;17(Suppl 1):S169–S177. doi: 10.1111/j.1540-8167.2006.00401.x

Figure 1.

Figure 1

Ranolazine (RAN) reversibly shortens action potential (AP) duration (APD) of ventricular myocytes isolated from canine failing hearts (HF).

Panel A: Representative APs of single left ventricular cardiomyocytes. Superimposed APs were recorded at a pacing rate of 0.5 Hz in the absence of drug (control), in the presence of ranolazine (10 μM) and after drug washout.

Panel B: Effect of ranolazine on APD at 90% repolarization (APD90) of ventricular myocytes stimulated at a rate of 0.5 Hz. Ranolazine at concentrations of 5, 10 and 20 μM significantly and reversibly shortened APD90. Data were pooled from 3 non-failing and 6 failing hearts. All APs longer than 2 s were excluded.

n= number of myocytes; * p < 0.05 vs. HF (ANOVA followed by Bonferroni’s post-hoc test against HF).