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. Author manuscript; available in PMC: 2006 Jun 23.
Published in final edited form as: Mol Vis. 2000 Dec 31;6:265–286.

Table 2.

Parameters for Analysis of RecRK Model

τE— Rate Limiting (Figs.3-5) τR— Rate Limiting (Fig. 6)
Value Lower Bound Upper Bound Value Lower Bound Upper Bound
“Front-End” Feedback Parameters
q3 1.17062 0.1 10 4.77044 0.1 10
q4 0.194099 0.1 10 8.84519 0.1 10
RKtot 7 7
Rectot 35 35
Kref,Ca 0.53 0.669028 0.1 1.2
w 2.5 1.5 2.5 2.5 1.5 2.5
“Front-End” Parameters
1/τb 0.05 0.005 0.05 0.00500023 0.005 0.05
1/τRi 0.334905 0.05 0.5 0.5 0.05 0.5
q5 10 0.01 10 0.0497478 0.01 10
νrp 1000 1000
τE 2.88 0.458034 0.2 0.6
Ca++, Ca++ -Buffer Parameters
fCa 0.3 0.2469
cDark 0.3 0.3
c0 0.02 0.02
γCa 96.28 50 150 79.2385 50 150
k1 0.603583 0.05 5 0.703409 0.05 5
k2 0.718945 0.05 5 0.777149 0.05 5
et 294.398 100 1000 881.304 100 1000
cGMP, Cyclase Parameters
βsub 1.68*10−5 1.68*10−5
βd 0.5 0.752485 0.2 4
Amax 20 200
Kc 0.137747 0.05 0.24 0.0830172 0.05 0.24
nCa 2.5 3.8 1.5 3.8
gDark 5 2
cGMP-Gated Channel, Photocurrent Parameters
ncg 2.58614 1.5 3.5 2.36128 1.5 3.5
Jd 17.34 17.34
Errors
ERRcombo 0.246417 0.515797
ERRml 0.745378 2.58888
ERRflash 0.081464 0.102766

Parameters are grouped according to functional elements of the model. All descriptions of parameters are given in Table 1. For each of the two rate-limiting cases analyzed (τE, τR), the columns of numbers show the optimized parameter value, and the lower and upper bounds used in the optimization. The latter are shown only for parameters that were actually optimized. The errors listed at the bottom of the Table are RMS errors for the fits to the Murnick & Lamb [2] saturated two-flash data (ERRM& L'; data from their Figure 3) and to the sub-saturated flash responses from Rieke & Baylor [16] (ERRflash; responses to the 4 lowest flash intensities shown in their Figure 4). The combined error (ERRcombo) was calculated as the square root ofthe product of the two other errors.