Table 3.
τE — Rate Limiting (Figs.9,10,13) | τR — Rate Limiting (Figs.11-13) | |||||
---|---|---|---|---|---|---|
Value | Lower | Upper | Value | Lower | Upper | |
Bound | Bound | Bound | Bound | |||
“Front-End” Feedback Parameters | ||||||
Kr | 1 | 0.01 | 1 | 0.754487 | 0.01 | 1 |
nr | 1.75626 | 1.5 | 3.5 | 1.76628 | 1.5 | 2.5 |
“Front-End” Parameters | ||||||
1/τb | 0.00605424 | 0.005 | 0.05 | 0.00506223 | ||
1/τRi | 0.276616 | 0.05 | 0.5 | 0.405197 | ||
τR | 0.724862 | 0.1 | 1 | 2.80803 | ||
νrp | 1000 | 1000 | ||||
τE | 2.88 | 0.456273 | ||||
Ca++, Ca++-Buffer Parameters | ||||||
fCa | 0.264506 | 0.291954 | ||||
CDark | 0.3 | 0.3 | ||||
C0 | 0.02 | 0.02 | ||||
γCa | 84.8887 | 50 | 150 | 93.6977 | 50 | 150 |
k1 | 2.71247 | 0.05 | 5 | 3.94229 | 0.05 | 5 |
k2 | 0.411885 | 0.05 | 5 | 0.223895 | 0.05 | 5 |
eT | 174.813 | 100 | 1000 | 228.784 | 100 | 1000 |
cGMP, Cyclase Parameters | ||||||
βsub | 1.68*10−5 | 1.68*10−5 | ||||
βd | 0.226277 | 0.2 | ||||
Amax | 24.4703 | 20 | 200 | 20 | 20 | 200 |
Kc | 0.105064 | 0.05 | 0.24 | 0.084256 | 0.05 | 0.24 |
nCa | 3.78534 | 1.5 | 3.8 | 3.06461 | 1.5 | 3.8 |
gDark | 2 | 2 | ||||
cGMP-Gated Channel, Photocurrent Parameters | ||||||
ncg | 2.9839 | 1.5 | 3.5 | 2.8557 | 1.5 | 3.4 |
Jd | 17.34 | 17.34 | ||||
Errors | ||||||
ERRcombo | 0.166388 | 0.197711 | ||||
ERRml | 0.392868 | 0.542604 | ||||
ERRflash | 0.0704692 | 0.0720411 |
Table format as in Table 2. Only parameters optimized have lower and upper bounds specified.