Table 2.

Parameters used for analyses of Nikonov et al. (1998) model

	(Fig. 2)			(Fig. 3)			(Fig. 4)			(Fig. 6)
	Nikonov et al. Parameters			Optimized			Optimized, τE* = 2 s			"Modern" parameters
Parameters	Value	Lower bound	Upper bound	Value	Lower bound	Upper bound	Value	Lower bound	Upper bound	Value	Lower bound	Upper bound
"Front-End" Parameters
τR*	0.43			0.351	0.1	0.99	0.17	0.050	0.49	0.49	0.050	0.49
τE*	1.4			1.051	1	4	2			1.292	1	3
νRP	6565.8	100	20000	1916.8	100	20000	2567.6	100	20000	5602	100	20000
R*(0)	0			0			0			0
E*(0)	0			0			0			0
Ca2+, Ca2+-Buffer Parameters
Cdark	0.385			0.250 a			0.553 a			0.625 a
Jex,sat	18.638			26.78	4	40	14.08	4	40	23.17	4	40
Jex,ss	3.618			3.615 a			3.615			6.507
Kex	1.6			1.6			1.6			1.6
Fca	0.1			0.1			0.1			0.18
Bca	15			11.74	10	200	55.32	2	200	2	2	200
Vcyto	1 × 10−12			1 × 10−12			1 × 10−12			1 × 10−12
F	96487			96487			96487			96487
fse	1			1			1			1
cGMP, Cyclase Parameters
Kc	0.1			0.0842	0.08	0.24	0.208	0.08	0.22	0.2	0.2	0.24
nca	2			2			2.714	1	4	2
Amax	30			3.254 a			4.034 a			17.22 a
βsub	1.9 × 10−5			1.9 × 10−5			1.9 × 10−5			1.9 × 10−5
gdark	2			2			2			2
βd	0.948			0.166	0.1	2	0.133	0.1	4	0.8	0.8	1.2
cGMP-Gated Channel, Photocurrent Parameters
ncg	2			2			1.5	1.5	3.5	2
Jd	72.296			72.296			72.296			72.296
Fdark	1			1			1			1
Rel Err	0.0226			0.00311			0.00696			0.01257

^aRoaming steady-state parameter.