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HCV blocks MAVS/IPS-1- and RIG-I-induced IFN-β expression. HCV blocks MAVS/IPS-1-mediated (A) or RIG-I-mediated (B) IFN-β induction. The experimental conditions were the same as in Fig. 4, except that MAVS/IPS-1 or RIG-I expression plasmids were cotransfected with the IFN-β promoter reporter plasmid.
