Table 2.

CDC reaction of tertiary amines with malonates

Tetrahydroisoquinoline (0.1 mmol), malonate (0.1 mmol), and TBHP (0.02 ml, 5–6 M in decane). [Reproduced with permission from ref. 25 (Copyright 2005, Wiley).]

*Isolated yields.

^†CuBr (0.005 mmol, 0.5 mol%), tetrahydroisoquinoline (1.0 mmol), malonate (1.0 mmol), and TBHP (0.2 ml, 5–6 M in decane); the reaction time is 43 h.

^‡Malonate (0.2 mmol).