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. 2006 Jun 1;103(24):9029–9033. doi: 10.1073/pnas.0603269103

Fig. 6.

Fig. 6.

The hypoxia-mediated reduction of E-cadherin expression and tumor cell migration involves the E-box-containing region of the promoter. H1299 cells were transfected with a plasmid containing the −80 to +10 region of the human E-cadherin promoter containing the two wild-type E-boxes (WT) or a version containing mutated E-boxes (mt). E-cadherin mRNA was measured 16 h after exposure to hypoxia by real-time RT-PCR (A) and cell migration from the edge of the dark field was scored 20 h after exposure to hypoxia (B).