Fig. 1.
Chromosome 21 analysis. (a) Nonparametric linkage (NPL) curve generated by genehunter (v2.5.1) for chromosome 21 (36, 37). Markers are indicated. Markers are shown from the p to q telomeres, and the CRF2 family is located at ≈22.5 cM. (b) Diagrammatic representation of the CRF2 family of genes found at Chr 21q22. Solid arrows represent polymorphisms typed in this study, and the dashed line represents the expanded region in which the genes are located. SNPs resulting in amino acid changes are shown in bold, and microsatellites are in italics.