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. 2006 Jun 5;103(24):9244–9249. doi: 10.1073/pnas.0600001103

Fig. 2.

Fig. 2.

Frequency of resistance against AP23464 and PD166326 alone and in combination with imatinib. (A) Frequency of resistance of BAF3 cells transformed with randomly mutagenized BCR/ABL. For each experiment, 150 × 106 BAF3 cells were transduced with randomly mutagenized BCR/ABL virus. After 16–20 h cells were divided into 15 subgroups and exposed to different drug concentrations, as indicated below each bar. Cells were then plated at a density of 0.25 × 106 per well of a six-well plate. The number of clones obtained per 106 cells from two independent experiments were averaged and plotted. (B) Frequency of resistance from the BAF3 cells harboring native, nonmutagenized BCR/ABL. For each experiment, 130 × 106 BAF3-BCR/ABL cells were divided into 13 subgroups and exposed to different drug concentrations, as indicated below each bar. Numbers below each bar represent number of resistant colonies from 107 BaF3 cells.