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. 2006 Jun 2;103(24):9345–9350. doi: 10.1073/pnas.0508875103

Fig. 4.

Fig. 4.

AAV-GDNF reduces the percentage of neurons with mHtt+ inclusions. WT mice never exhibited mHtt+ inclusions in the striatum (A). In contrast, transgenic mice, regardless of group (the example above is an AAV-eGFP-injected mouse), showed evidence of mHtt+ inclusions in the striatum (B). (E) Evidence of cells with robust inclusions. (C) Whereas no differences in the total number of striatal inclusions were observed between AAV-GDNF-injected mice and AAV-eGFP-injected mice (P > 0.05), a significant decrease in the percentage of neurons with inclusions was observed (D) (P < 0.01). (Scale bar: A and B, 500 μm; E, 10 μm.) Inclusion quantification was performed at week 16 of life.