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. 2006 May 23;103(23):8792–8797. doi: 10.1073/pnas.0603245103

Fig. 5.

Fig. 5.

Role of LRR insertions and basic residue patches in dsRNA recognition. (A) Location of mutated residues. Groups of positively charged residues in patches 1 and 2, shown in blue, were mutated to alanine. The inserts in LRRs 12 and 20, shown in green, were deleted. (B) Responsiveness of TLR3 mutants to pI:pC. Deletions of LRR inserts are shown in green, and mutants in the positively charged patches are color-coded blue. In patch 1, mutant Δ4 contains four mutations, R65A, K89A, K117A, and K147A; Δ6 contains six mutations, R65A, K89A, K117A, K137A, K139A, and K147A; and Δ8 contains eight mutations, R65A, K89A, K117A, K137A, K139A, K145A, K147A, and K165A. In patch 2, Δ3 contains three mutations, K335A, K345A, K371A; and Δ7 contains seven mutations, R331A, K335A, K345A, K371A, R394A, K416A, and K418A. ∗, significant loss in activity (P < 0.05).