Table 1.
QTLa | MMU | Peak LOD cM (Mbp)b | Full congenic named | Abbreviation | Min. interval (Mbp)e |
Wg1 | 2 | 31 (52) | B6.CAST-(D2Mit1-D2Mit160)N(6) | B62P | 3.8–84.8 |
HG.CAST-(D2Mit1-D2Mit160)N(6) | HG2P | 3.8–84.8 | |||
B6.CAST-(D2Mit322-D2Mit439)N(6) | B62PM | 42.9–92.0 | |||
HG.CAST-(D2Mit322-D2Mit439)N(6) | HG2PM | 42.9–92.0 | |||
Wg2 | 2 | 59–83c | B6.CAST-(D2Mit329-D2Mit490)N(6) | B62M | 74.9–138.6 |
Carp1 | (115–150) | HG.CAST-(D2Mit329-D2Mit490)N(6) | HG2M | 74.9–138.6 | |
Cara1 | B6.CAST-(D2Mit329-D2Mit457)N(6) | B62D | 74.9–181.8 | ||
Feml1 | HG.CAST-(D2Mit329-D2Mit457)N(6) | HG2D | 74.9–181.8 | ||
Q1Ucd1 -w26 | 1 | 16 (35) | HG.CAST-(D1Mit118-D1Mit250)N(6) | HG1 | 4.0–70.6 |
Carfhg1 | 5 | 38 (100) | HG.CAST-(D5Mit229-D5Mit158)N(6) | HG5 | 30.7–114.2 |
Wg3 | 8 | 45 (98) | HG.CAST-(D8Mit9-D8Mit198)N(6) | HG8 | 70.2–104.1 |
Carfhg2 | 9 | 10 (30) | HG.CAST-(D9Mit249-D9Mit133)N(6) | HG9 | 9.1–84.2 |
Feml2 | 9 | 20 (48) | HG.CAST-(D9Mit249-D9Mit133)N(6) | HG9 | 9.1–84.2 |
Carp2
Wg4 Cara2 |
11 | 46–50 (80–90) | HG.CAST-(D11Mit260-D11Mit255)N(6) | HG11 | 61.9–114.3 |
Feml3
Carp3 Cara3 |
17 | 46–48 (70–76) | HG.CAST-(D17Mit213-D17Mit142)N(6) | HG17 | 14.8–77.3 |
QTL, quantitative trait locus; MMU, mouse chromosome; LOD, log of the odds
a QTL MGI [59] nomenclature. Q1Ucd1-w26 never received an official MGI name, because it only reached a suggestive level of significance; hg modifier QTL are in bold [24].
b Mbp position according to the August 2005 mm7 UCSC [28] genome assembly (NCBI Build 35), peak LOD from [24].
c In the linkage analysis performed in [24], the peak location for Wg2, Carp1, Cara1 and Feml1 was 59–63 cM (115–120 Mbp) in hg/hg F2 mice and 78–83 cM (135–150 Mbp) in +/+ F2 mice.
d Full congenic name consists of three parts: 1. B6.CAST, indicates the recipient strain is B6 and the donor strain is CAST; HG.CAST, indicates the recipient strain is HG and the donor strain is CAST; 2. markers defining the minimal congenic interval; 3. the number of backcrosses used for speed congenic development.
e Represents the minimum genomic region spanned by CAST donor alleles.