Table 7.

Nonsynonymous SNP in MMU2, 9 and 17 hg modifier candidate genes predicted by SIFT and Polyphen to alter protein function

Gene	MMU	Mbp	AAÄa	B6/CASTb Polyphen	CAST/B6 Polyphen	B6/CAST SIFT	CAST/B6 SIFT
Nmi	2	52.0	R243C	B	B	T	D
Mtx2	2	74.7	T1099M	PSD	PSD	T	D
Ubr1	2	120.6	A1371T	B	B	D	T
Ptpns1	2	129.3	H224N	PBD	PBD	T	T
Ubce7ip5	2	130.3	A314P	PSD	PSD	T	T
	2		I366T	B	B	T	D
Plcg1	2	160.5	T1165A	B	B	T	D
Mmp9	2	164.7	A514P	B	B	D	D
	2		P639L	PBD	PBD	T	T
Tyk2	9	21.0	R234H	PSD	PSD	T	T
			C831S	PSD	PSD	T	T
			T1099M	PSD	PSD	T	D
Vav	17	55.5	Q29H	PSD	PBD	T	T
			Q53H	PBD	PSD	T	T
			Q65H	PBD	PSD	T	D

MMU, mouse chromosome; AA, amino acid; PBD, probably damaging, PSD, possibly damaging; B, Benign; T, tolerated and D, deleterious.

^a Amino acid change, first residue listed corresponds to the CAST allele and second corresponds to the B6 allele.

^b Indicates which allele was designated as "mutant", i.e. B6/CAST, B6 allele is mutant and CAST is wild type.