. Author manuscript; available in PMC: 2006 Jun 27.

Published in final edited form as: Chem Res Toxicol. 2006 Jun;19(6):818–827. doi: 10.1021/tx0600402

Table 2.

Calculated Percent of Dose of Metabolites Excreted (0–12 h) after Administration of Both Arecoline and Arecaidine to the Mouse^a

	% dose (mean ± SD) eliminated in 0-12 h urine as:
administration	arecoline	arecaidine	arecoline N oxide	N-Methylnipecotic acid
arecoline (20 mg/kg p.o.)	0.3 ± 0.4	13.1 ±6.3	19.0 ± 9.0	30.3 ± 11.1
arecoline (20 mg/kg i.p.)	0.4 ± 0.4	7.1 ±6.2	7.4 ± 2.8	13.5±2.6
arecaidine (20 mg/kg p.o.)	0	23.0 ±11.2	0	37.7±0
arecaidine (20 mg/kg i.p.)	0	15.1 ±8.3	0	14.8±6.3

0, not detected.