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. Author manuscript; available in PMC: 2006 Jun 27.
Published in final edited form as: J Biol Chem. 2005 Dec 21;281(9):5965–5972. doi: 10.1074/jbc.M511270200

Figure 3. Schematic of interactions of the ligand with the dicarboxylate site residues.

Figure 3

Eight strong hydrogen bonds to the four carboxylate oxygens locate the ligand in the binding site and maintain a nonplanar conformation. In addition, His364 is positioned to interact with carboxylate oxygen O1 or an oxygen on C3 in the inhibitor or a reaction intermediate. The green dotted line shows the interaction of catalytic base Arg297 with C3 of the ligand, from which a proton is extracted during oxidation of succinate.