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. 2006 Apr 28;91(2):744–758. doi: 10.1529/biophysj.105.073312

FIGURE 7.

FIGURE 7

H6-SNAP25B reduces the extension of Sx1A-Sb2 interactions. (A) Cofunctionalized tips with equimolar ratio of Sx1A-H6/H6-SNAP25B and Sx1A-H6/H6 were used to probe Sb2-H6 functionalized coverslips as shown in the force-distance curves (B). Distribution of the measured extensions (C) and forces (D) at rupture. (E) Summary of the experiments indicate that there is no significant difference in the rupture force, whereas there is significant reduction in the extension at rupture when the tips contained Sx1A-H6/H6-SNAP25B, as compared to when the tips were cofunctionalized with Sx1A-H6/H6. Student's t-test, P < 0.01 (**). Arrowheads in C and D indicate mean values. Retraction velocity, 1.6 μm/s. Drawing in A is not to scale.