TABLE 3.
Botulinum neurotoxin type B affects the interaction between syntaxin 1A and synaptobrevin 2
| Before (B)
|
After (A)
|
||||||
|---|---|---|---|---|---|---|---|
| Treatment | Positive | Total | Positive B (%) | Positive | Total | Positive A (%) | A/B |
| Sham | 80 | 234 | 34 | 75 | 208 | 36 | 1.1 |
| BoNT-B | 222 | 624 | 36 | 193 | 678 | 28 | 0.8 |
| BoNT-B + Zn2+ | 138 | 390 | 35 | 82 | 1170 | 7 | 0.2 |
| Zn2+ | 84 | 234 | 36 | 85 | 234 | 36 | 1.0 |
| BoNT-B + TPEN | 82 | 234 | 35 | 89 | 260 | 34 | 1.0 |
| TPEN | 89 | 234 | 38 | 98 | 260 | 38 | 1.0 |
Note: Sham represents a control for the injection of the reagents (treatment) into the AFM fluid chamber (for details see Materials and Methods).
Abbreviations: BoNT-B, botulinum neurotoxin type B; TPEN, tetrakis-(2-pyridilmethyl)ethylenediamine.