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Apoptosis and impaired G2/M cell cycle checkpoint in Wee1-/- embryos. (A, B) TUNEL assay revealed increased apoptosis in Wee1-/- embryos. (C,D) Mitotic cells in E2.5 embryos. (E,F) Mitotic index of E2.5 and E3.5 embryos. Each graph bar summarizes data obtained from at least 4 embryos.
