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. 2006 Jul 3;116(7):1776–1783. doi: 10.1172/JCI29044

Figure 3. Integration of intertissue signaling by AMPK.

Figure 3

Adipocyte-derived leptin reduces food intake though inhibition of hypothalamic AMPK. Leptin increases skeletal muscle fatty acid oxidation via direct activation of AMPK and the hypothalamus–sympathetic nervous system axis. The involvement of hypothalamic AMPK in leptin-induced skeletal muscle lipid oxidation and glucose uptake is unknown. Adiponectin is secreted by adipose tissue and increases skeletal muscle lipid oxidation and glucose uptake, as well as suppressing liver glucose production by activating AMPK.