Table 2.
Growth progression of IST-Mes3 cell line after orthotopic implantation in nude mice.
| Days after implantation | <56 | 60 | 65 | 71 | 73 | 80 | 87 | 94 | 98 |
| N° of animals with tumor nodules1 | 0/5 | 1/5 | 2/5 | 1/5 | 1/5 | 0/5 | 1/5 | 1/5 | 2/5 |
| N° of tumor nodules detected in each animal | - | >20 | >20 | >20 | >20 | - | >20 | >20 | >20 |
2 × 106 IST-Mes3 cells were injected into the pleural cavity of nude mice. Five animals were sacrificed when they became dyspneic or at indicated times and tumor nodules were counted, measured, removed and frozen for immunohistochemical analysis. Data shown report tumor development in individual animals.