Figure 5.
The effects of pretreatment with a glucagon receptor antagonist on the actions of exogenous glucagon on refractive error, ocular growth, and choroidal thickness. Form-deprived experimental eyes were injected with (1) saline both injections (SAL/SAL); (2) saline followed by glucagon (10−6 M in the syringe (SAL/GLUC); (3) des-Phe6-antagonist (10−4 M in the syringe) followed by saline (ANT/SAL); and (4) des-Phe6-antagonist, followed by glucagon (ANT/GLUC). Bars and error bars, mean interocular difference (T – C eye) ± SD of the mean for (a) refractive error, (b) ocular wet weight, (c) vitreous chamber depth, and (d) choroidal thickness for (n) animals. *Effects of a treatment were significantly different from the SAL/SAL group (ANOVA, Newman-Keuls post test, P < 0.05).