Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Lymphodepletion with total-body radiation augmented tumor regression mediated by adoptively transferred antigen-specific CD8+ T cells. Mice bearing large unmanipulated B16 melanoma tumors were treated with adoptive transfer of activated pmel-1 cells, vaccination with rFPgp10025–33, and IL-2. Either no lymphodepletion (PFI) or lymphodepletion with 5 Gy total-body irradiation (PFI-XRT) was administered before cell transfer. Radiation alone (XRT) had a negligible effect on tumor growth.
