FIGURE 5.

Dexamethasone impaired proliferation of naive but not activated antigen-specific CD8⁺ T cells. A, H³-thymidine incorporation by naive and activated pmel-1 CD8⁺ T cells cocultured with hgp100 peptide–pulsed irradiated splenocytes. H³-thymidine incorporation by naive cells but not by activated cells was diminished. B, H³-thymidine incorporation by naive and activated pmel-1 CD8⁺ T cells cocultured with irradiated splenocytes pulsed with hgp100 at 1 × 10⁻⁷ M in titrated concentrations of dexamethasone relative to H³-thymidine incorporation in the absence of dexamethasone. Proliferation of naive cells was impaired, whereas proliferation of activated cells was not affected.