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. Author manuscript; available in PMC: 2006 Jul 4.
Published in final edited form as: J Immunother. 2005;28(6):517–524. doi: 10.1097/01.cji.0000177999.95831.7b

FIGURE 6.

FIGURE 6

Function of naive and activated antigen-specific CD8+ T cells was impaired by dexamethasone, but naive cells were more significantly suppressed. A, IFNγ release by naive and activated pmel-1 CD8+ T cells cocultured with hgp100 peptide–pulsed irradiated splenocytes. IFNγ release by naive and activated cells was diminished. B, IFNγ release by naive and activated pmel-1 CD8+ T cells cocultured with irradiated splenocytes pulsed with hgp100 at 1 × 10−7 M in titrated concentrations of dexamethasone relative to H3-thymidine incorporation in the absence of dexamethasone. Naive cell function was more impaired than activated cell function.