Figure 1.

Comparison of the domain structure of ADAM 23 and human ADAMs. The amino acid sequences of the regions around the consensus sequence for metalloproteinases (HEXXHXXGXXH) and the putative integrin-binding loops of ADAMs are shown. Sequences for human fertilin α (ADAM 1) and cyritestin 1 (ADAM 3) are not included, because their respective genes are not functional (Jury et al., 1997; Frayne and Hall, 1998). The disintegrin domain of decysin is truncated and lacks the region compared in the alignment of the remaining family members. All amino acid sequences were extracted from the SwissProt database. The modular structure of members of the recently described ADAM-TS subfamily containing thrombospondin-1 repeats is shown by Hurskainen et al. (1999).