Figure 5.

Mitochondrial translation in representative homoplasmic cybrid clones (notation as in Figure 2). (A) Fluorogram of mitochondrial translation products. The predicted mtDNA-encoded polypeptides are shown at left. (B) Nucleotide and deduced amino acid sequences across the rearrangement breakpoint straddling the authentic COX II and Cyt b genes (see Figure 1). Numbers denote map positions inside and outside the deleted region. Note that the conceptual translation of the portion of the fusion mRNA located beyond the breakpoint is out of frame, resulting in a premature termination codon.