Table 4.

Quantitation of transcripts

	Genes/genomea			Genes/cell			Transcripts/cell		Transcripts/gene/cell
	WT a	Dup b	Del c	WT d	Dup e	Del f	Dup/WT A	Del/WT B	Dup/WT C = (Ad)/e	Del/WT D = (Bd)/f	Del/Dup E = D/C
A. 1-copy genes
tRNALys	1	1	0	13,056	8,550	0	0.55b	0	0.84	–	–
ATP 8/ATP 6	1	1	0	13,056	8,550	0	0.83	0	1.27	–	–
COX III	1	1	0	13,056	8,550	0	0.87b	0	1.33	–	–
ND3	1	1	0	13,056	8,550	0	0.60	0	0.92	–	–
ND4L/ND4	1	1	0	13,056	8,550	0	0.45b	0	0.69	–	–
ND5	1	1	0	13,056	8,550	0	0.51	0	0.78	–	–
tRNAGlu	1	1	0	13,056	8,550	0	0.73	0	1.11	–	–
Average							0.65	0	0.99	–	–
Predicted valuec							0.66	0	1.00	–	–
B. 2-copy genes
ND1	1	2	2	13,056	17,100	23,750	0.82	1.86b	0.62	1.02	1.64
ND2	1	2	2	13,056	17,100	23,750	1.05	1.77b	0.80	0.97	1.21
COX I	1	2	2	13,056	17,100	23,750	0.64b	0.32b	0.48	0.18	0.38
12S rRNA	1	2	2	13,056	17,100	23,750	0.71	0.59b	0.54	0.32	0.59
16S rRNA	1	2	2	13,056	17,100	23,750	0.78	0.73	0.59	0.40	0.68
tRNAPhe	1	2	2	13,056	17,100	23,750	1.07	0.74	0.82	0.41	0.50
tRNASer(UCN)	1	2	2	13,056	17,100	23,750	1.31b	0.93	1.00	0.51	0.51
Average							0.91	0.99	0.69	0.54	0.79
Predicted valuec							1.32	1.82	1.00	1.00	1.00

^aGenomes per cell: 13,056 in monomeric wild-type (WT) lines; 8550 in duplication (Dup) lines; 11,875 in deletion dimer (Del) lines. 

^bSignificant difference compared with wild-type value (p < 0.05). 

^cAssumes that transcription in rearranged lines is regulated in the same way as in wild-type lines. Thus, for 1-copy genes, transcription in Dup lines is 1× (8,550/13,056) relative to WT lines. For 2-copy genes, transcription in Dup lines is 2× (8,550/13,056) and in Del dimer lines is 2× (11,875/13,056) relative to WT lines.