Figure 4.

Human CLIC5 has homology to CLIC4, CLIC3, CLIC2, CLIC1, and the C-terminal half of bovine p64 (p64-C). (A) Sequence alignment. Amino acid residues are numbered on the left. Identities are boxed. The two conserved hydrophobic domains are underlined. Three highly conserved tyrosine residues are indicated by asterisks. The arrowhead indicates a potential phosphorylation site for cAMP-dependent protein kinase that is conserved in CLIC5, CLIC4, and p64-C. (B) Kyte-Doolittle hydrophobicity plots. (C) Dendrogram of CLIC proteins.