Table 2.

Clinical Characteristics of Subjects with Pure Alzheimer's Disease (AD) (n = 30) and AD with Significant Vascular Lesions (AD/V) (n = 18)

Characteristic	Pure AD	AD/V	P-value
Age at first noted symptom, mean ± SD	75.03 ± 7.3	76.89 ± 6.5	.378
Age at intake, mean ± SD	77.35 ± 7.0	78.98 ± 6.4	.424
Age at last assessment, mean ± SD	79.56 ± 6.5	81.38 ± 6.4	.351
Diagnostic and Statistical Manual of Mental Disorders,			.031
Third Edition, Revised diagnosis at last assessment, n (%)*
AD	26 (86.7)	10 (55.6)
Dementia, other	4 (13.3)	6 (33.3)
No clinical dementia	0 (0)	2 (11.1)
Age at death, mean ± SD	80.55 ± 6.6	82.56 ± 6.3	.306
Years between last assessment and death, mean ± SD	0.98 ± 0.8	1.17 ± 0.9	.455
Years between symptom onset and death, mean ± SD	5.51 ± 2.6	5.67 ± 2.2	.835
MMSE score at baseline, mean ± SD†	18.63 ± 5.9	22.72 ± 4.9	.017
Final MMSE score, mean ± SD‡	11.13 ± 7.3	16.11 ± 7.1	.026
Change in MMSE score, mean ± SD§	9.78 ± 5.3	7.00 ± 5.4	.114
Change in MMSE score/years from enrollment to last intake, mean ± SD§	4.07 ± 2.9	3.28 ± 3.3	.424

^*Because of small cell sizes, “dementia, mixed” was combined with “dementia, other.” One AD/V case was clinically identified as mixed dementia. Pearson chisquare = 6.95, df = 2, P = .031.

^†Student t test, t = −2.48, df = 46, P = .017.

^‡Student t test, t = −2.31, df = 46, P = .026.

^§Data available in only 23 pure AD and 17 AD/V cases that had two or more annual assessments.

MMSE = Mini-Mental State Examination.