Skip to main content
. 2000 May;11(5):1631–1643. doi: 10.1091/mbc.11.5.1631

Figure 4.

Figure 4

Figure 4

Sequence analysis of the gdt1 gene product. (A) Amino acid sequence of the gdt1 gene product. The gdt1 protein is composed of 1561 amino acid residues and contains four putative transmembrane domains (bold letters) in the direction of N-i-o-i-o-i-C (analyzed by the EMBL TMpred program). The putative kinase domain is underlined; the expressed D1 peptide sequence used to generate the antiserum is shown by dotted underlining. (B) Multiple alignment of the putative gdt1 kinase domain with other kinases. The 11 subdomains of protein kinases are shown below the sequence and are separated by colons. Conserved amino acids are indicated by bold letters. MMU76762, murine Fer tyrosine kinase (K. Letwin and T. Pawson, unpublished data); MMECK, a receptor tyrosine kinase implicated in pattern formation in mice (Ganju et al., 1994); CEK4, chicken eph-related receptor tyrosine kinase (Sajjadi et al., 1991); TESK1B, serine/threonine kinase from rat (Toshima et al., 1995); PYK2A, tyrosine kinase from D. discoideum (Tan and Spudich, 1992); RTRK, neutrophic receptor tyrosine kinase from Drosophila melanogaster (Wilson et al., 1993).