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. 2000 May;11(5):1775–1787. doi: 10.1091/mbc.11.5.1775

Figure 8.

Figure 8

Endocytosis and site of entry of CNF1. Comparison with others toxin. RT, ricin toxin; CT, cholera toxin; ST, Shiga toxin; DT, diphtheria toxin; CNF1, cytotoxic necrotizing factor 1; ER, endoplasmic reticulum; M, microtubules; ECV, endocytic carrier vesicles; EE, early endosome; LE, late endosome; Ly, lysosome; Cl, clathrin-coated invagination; C, caveolae invagination; NCC, non-clathrin noncaveolae endocytic invagination; EF2, elongation factor 2; aGs, heterotrimeric GTP-binding protein a component; Rib, 28S ribosome; Rho, Rho GTP-binding protein; TGN, trans-Golgi network. Open arrows indicate sites where toxins are supposed to be released into the cytosol. Boxed abbreviations indicate the intracellular targets of toxins.