TABLE 2.
Time point | Strain (no. of mice) | No. of mice with the following histopathology scorea:
|
||||
---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | ||
Liver | ||||||
8 h | MGH-2 (8) | 5 | 2 | 1 | 0 | 0 |
JH2-2 (8) | 6 | 2 | 0 | 0 | 0 | |
24 h | MGH-2 (6) | 4 | 2 | 0 | 0 | 0 |
JH2-2 (7) | 4 | 3 | 0 | 0 | 0 | |
72 h | MGH-2 (7) | 2 | 0 | 0 | 5 | 0 |
JH2-2 (7) | 2 | 5 | 0 | 0 | 0 | |
7 days | MGH-2 (7) | 0 | 3 | 3 | 0 | 1 |
JH2-2 (7) | 1 | 1 | 3 | 2 | 0 | |
10 days | MGH-2 (4) | 4 | 0 | 0 | 0 | 0 |
JH2-2 (5) | 3 | 0 | 1 | 1 | 0 | |
Kidney | ||||||
8 h | MGH-2 (8) | 8 | 0 | 0 | 0 | 0 |
JH2-2 (8) | 8 | 0 | 0 | 0 | 0 | |
24 h | MGH-2 (6) | 6 | 0 | 0 | 0 | 0 |
JH2-2 (7) | 5 | 2 | 0 | 0 | 0 | |
72 h | MGH-2 (7) | 7 | 0 | 0 | 0 | 0 |
JH2-2 (7) | 2 | 5 | 0 | 0 | 0 | |
7 days | MGH-2 (7) | 2 | 0 | 1 | 4 | 0 |
JH2-2 (7) | 1 | 1 | 3 | 2 | 0 | |
10 days | MGH-2 (4) | 3 | 1 | 0 | 0 | 0 |
JH2-2 (5) | 2 | 1 | 1 | 1 | 0 |
The severity of histopathology was graded as 0 to 4 for each tissue section as described in Materials and Methods.