TABLE 3.

Protective efficacy against acute fatal pneumonia due to P. aeruginosa after active nasal immunization of C3H/HeN mice with E. coli HB101 or PAO1ΔaroA

Challenge strain	Serogroup	LD50(CFU)	Inoculum (CFU)	Multiple of LD50a	No. of surviving mice/no. of mice challenged in vaccine group:
					E. coli HB101	PAO1ΔaroA
PAO1	O2/O5	3 × 107	6 × 108	20	0/10	7/10b
170003	O2/O5	8 × 107	5 × 108	6	0/10	7/12b
IATS O16	O2/O5	6 × 107	1 × 109	17	0/10	4/10c
Fisher IT-3	O2/O5	1 × 108	4 × 108	4	0/6	1/7
Fisher IT-7	O2/O5	7 × 106	2 × 108	29	2/10	9/10c
Fisher IT-4	O1	6 × 108	7 × 108	1.2	0/5	0/6
6294	O6	5 × 107	3 × 108	6	1/6	0/6
6206	O11	4 × 106	3 × 108	75	0/10	0/10

^aThe LD₅₀ values were determined by probit or logit analysis.

^bP < 0.01 (Fisher exact test).

^cP = 0.09 (Fisher exact test).