TABLE 4.
Protective efficacy against acute fatal pneumonia due to P. aeruginosa after passive immunization of C3H/HeN mice with rabbit IgG specific for E. coli HB101 or PAO1ΔaroA
| Challenge strain | Inoculum (CFU) | IgG dose (mg) (route) | No. of surviving mice/no. of mice challenged in IgG group:
|
|
|---|---|---|---|---|
| E. coli HB101 | PAO1ΔaroA | |||
| ExoU+ PAO1 | 1 × 107 | 1 (i.p.) | 0/5 | 5/5a |
| 1 × 107 | 0.25 (i.n.) | 0/4 | 4/4a | |
| 5 × 107 | 1 (i.p.) | 0/5 | 0/5 | |
| 5 × 107 | 1 (i.p.), 0.25 (i.n.) | 0/4 | 3/4b | |
| PAO1 | 6 × 108 | 1 (i.p.) | 0/4 | 0/4 |
| 6 × 108 | 1 (i.p.), 0.25 (i.n.) | 0/4 | 0/4 | |
| 6 × 108 | 2 (i.p.), 0.5 (i.n.) | 0/4 | 0/4 | |
| 6 × 108 | 5 (i.p.), 0.5 (i.n.) | 0/2 | 0/2 | |
| 170003 | 5 × 108 | 1 (i.p.) | 0/5 | 0/5 |
| Fisher IT-7 | 2 × 108 | 1 (i.p.) | 0/5 | 0/5 |
a
P < 0.05 (Fisher exact test).
b
P = 0.14 (Fisher exact test).