TABLE 1.
Summary of effects of hinge mutations in IgA1 on susceptibility to cleavage by IgA1 proteases from strains of different species of streptococci
| IgA1 antibody | Resulta for strain (source of IgA1 protease):
|
|||||||
|---|---|---|---|---|---|---|---|---|
| S. pneumoniae SK690 | S. oralis SK10 | S. mitis SK564 | S. mitis SK597 | S. mitis SK599 | S. sanguis SK4 | S. sanguis SK1 | S. sanguis SK49 | |
| Wild-type IgA1 | + | + | + | + | + | + | + | + |
| P227T | + | +/− | − | − | − | − | − | − |
| T228P | + | +/− | − | + | − | − | − | − |
| T228V | + | +/− | +/− | + | + | +/− | − | +/− |
| T228/236V | + | +/− | +/− | + | + | +/− | − | +/− |
a
Antibody susceptibility to cleavage by protease: +, sensitive; +/−, partially sensitive; −, resistant.