TABLE 1.
Results of harvests of M. leprae from mice inoculated with the first inoculum
| Materiala | No. of AFB per footpad (105)
|
Pb | |
|---|---|---|---|
| Individual harvests | Median | ||
| Control | 33.6, 20.2, 18.9, 15.1, 11.5, 8.70, 6.39, 6.04, 5.06, 4.70, 4.62, 3.90, 3.37, 3.36, 1.69 | 6.04 | |
| FIA | 8.17, 6.12, 3.55, 3.28, 2.31, 2.22, 1.60, 1.07, 0.89, 0.44, 0.18, 0.089, <0.089 | 1.60 | |
| CW skeleton | 73.3, 13.5, 9.14, 8.61, 7.72, 7.46, 5.24, 1.51, 1.42 (2)c | 7.59 | 0.782 |
| CW skeleton in FIA | 2.13, 2.04, 0.98, 0.80, 0.53 (2), 0.44, 0.27, 0.18, 0.089 (2), <0.089 | 0.48 | 0.0602 |
| ML cytosol/MLSA | 3.37, 2.75, 2.13, 1.78, 1.60, 1.24 (2), 1.15, 0.62, 0.44, 0.27, 0.18 | 1.24 | 0.00004 |
| ML cytosol/MLSA in FIA | 0.53, 0.36 (2), 0.27, 0.18 (3), 0.089 (2), <0.089 | 0.18 | 0.0107 |
| ML membrane | 4.44, 3.46, 2.84, 2.66, 2.04, 1.69, 1.33, 1.15, 0.98, 0.80 | 2.04 | 0.00034 |
| ML membrane in FIA | 0.44 (2), 0.27 (2), 0.18 (3), <0.089 (3) | 0.18 | 0.0073 |
| HKML (2 × 107) | 1.60, 0.89, 0.80, 0.44, 0.36, 0.27, 0.18, 0.089 (2), <0.089 | 0.32 | 0.00003 |
| HKML (2 × 107) in FIA | 0.89, 0.62, 0.36 (2), 0.27, 0.18, 0.089, <0.089 (3) | 0.22 | 0.00003 |
a
CW, cell wall; ML, M. leprae.
b
P, the probability that these results were drawn from the same population as those of the corresponding control, determined by means of the Mann-Whitney U test.
c
Number of footpads with indicated result; in all other cases, only a single footpad yielded the indicated result.