TABLE 1.
Mouse strains used
| Mouse straina | Abbreviation | Mutation | Known immunological defect |
|---|---|---|---|
| C57BL/6J | B6 | None | None |
| B6.129S2-Igh-6tm1Cgn | B6 Igh6−/− | Induced deletion of membrane exon of μ heavy chain | Block of B-cell maturation at pre-B cells |
| B6.Cg-Foxn1nu | B6 NUDE | Forkhead box N1 | No T lymphocytes |
| C57BL/6 JH−/− | B6 JHD | Induced deletion of JhD segment | Block of B-cell maturation at pre-B cells |
| B6.CB17-Prkdcscid/SzJ | B6 SCID | Natural mutation in Prkdc locus | No B or T cells |
| B6.129P2-Fcgr3tm1Sjv | B6 FcgRIII−/− | Induced mutation in Fcg3 | No FcRγ3 |
| B6.129P2-Fcerg1tm1 | B6 FcRg−/− | Induced mutation in Fcg1 | No FcRγ1, FcRγ3, and FcRε1 |
| B6.129S6 | B6 | None | None |
| C57BL/6 CD1−/− | B6 CD1−/− | Induced mutation at the CD1 locus | No CD1-mediated antigen presentation |
| CBA/CaJ | CBA/Ca | None | None |
| CBA/CaHN-Btkxid/J | CBA/N | Natural mutation at Btk locus | No B1 B cells; other defects as well |
| BALB/cByJ | BALB/c | None | None |
| BALB/c JHD | BALB/c JHD | Same as in C57BL/6 JH−/− | Same as in C57BL/6 JH−/− |
| BALB/c Tcrbnull | BALB/c TCR-β−/− | Induced mutation in TCR-β locus | No TCR-αβ T cells |
| CBySmn.CB17-Prkdcscid/J | BALB/c SCID | Same as in B6.CB17-Prkdcscid/SzJ | Same as in B6.CB17-Prkdcscid/SzJ |
| B6.129S6-Iitm1Liz | B6 Ii−/− | Induced mutation at the Ii locus | No MHC class II antigens or CD4 T cells |
a
All mice from the Jackson Laboratory came from the research colonies of L. D. Shultz, except C57BL/6 JH−/− were from William Weidanz, Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, and BALB/c JHD were from Mark Shlomchik, Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, Conn.