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. 2006 May 10;7:111. doi: 10.1186/1471-2164-7-111

Table 2.

Frequencies of single nucleotide polymorphisms (SNPs) identified at MRP1

No.* SNP ID** Region Protein residue dbSNP (rs) Population*** n Allele frequency (%) No. SNP ID Region Protein residue dbSNP (rs) Population n Allele frequency (%)
C T C T
SNPu1 5'UTR/-51 C>T 5'UTR - - CH 36 100.00 0.00 SNPe4 E8/825 T>C Exon 8 Val>Val rs246221 CH 36 36.11 63.89
ML 35 98.57 1.43 ML 35 24.29 75.71
IN 35 100.00 0.00 IN 35 11.43 88.57
CAU 36 100.00 0.00 CAU 36 13.89 86.11
C T C T
SNPu2 5'UTR/-46 C>T 5'UTR - - CH 36 100.00 0.00 SNPe5 E9/1062 T>C Exon 9 Asn>Asn rs35587 CH 36 38.89 61.11
ML 35 98.57 1.43 ML 35 40.00 60.00
IN 35 100.00 0.00 IN 35 20.00 80.00
CAU 36 100.00 0.00 CAU 36 31.94 68.06
C T A G
SNPe1 E2/218 C>T Exon 2 Thr>Ile - CH 36 98.61 1.39 SNPi11 I9/8 A>G Intron 9 - rs35588 CH 36 61.11 38.89
ML 35 97.14 2.86 ML 35 60.00 40.00
IN 35 100.00 0.00 IN 35 80.00 20.00
CAU 36 100.00 0.00 CAU 36 68.06 31.94
A G A G
SNPi1 I2/26 G>A Intron 2 - rs8187843 CH 36 0.00 100.00 SNPi12 I9/79 G>A Intron 9 - - CH 36 0.00 100.00
ML 35 0.00 100.00 ML 35 0.00 100.00
IN 35 1.43 98.57 IN 35 1.43 98.57
CAU 35 7.14 92.86 CAU 36 0.00 100.00
A T G T
SNPi2 I2/-151 A>T Intron 2 - - CH 36 98.61 1.39 SNPe6 E10/1299 G>T Exon 10 Arg>Ser - CH 36 100.00 0.00
ML 35 100.00 0.00 ML 35 100.00 0.00
IN 35 100.00 0.00 IN 35 100.00 0.00
CAU 36 100.00 0.00 CAU 36 98.61 1.39
G T C T
SNPi3 I2/-93 G>T Intron 2 - - CH 36 100.00 0.00 SNPi13 I10/64 C>T Intron 10 - rs28363993 CH 36 100.00 0.00
ML 35 100.00 0.00 ML 35 100.00 0.00
IN 35 98.57 1.43 IN 35 97.14 2.86
CAU 36 100.00 0.00 CAU 36 100.00 0.00
C G A C
SNPi4 I2/-33 C>G Intron 2 - - CH 36 100.00 0.00 SNPi14 I10/91 C>A Intron 10 - - CH 36 0.00 100.00
ML 35 98.57 1.43 ML 35 1.43 98.57
IN 35 100.00 0.00 IN 35 4.29 95.71
CAU 36 100.00 0.00 CAU 36 0.00 100.00
G T C T
SNPi5 I3/-288 T>G Intron 3 - rs4148335 CH 36 2.78 97.22 SNPi15 I11/-95 T>C Intron 11 - - CH 36 1.39 98.61
ML 34 1.47 98.53 ML 35 0.00 100.00
IN 35 15.71 84.29 IN 35 0.00 100.00
CAU 34 14.71 85.29 CAU 36 0.00 100.00
A C A G
SNPi6 I3/-196 A>C Intron 3 - rs4148336 CH 36 97.22 2.78 SNPi16 I11/-78 G>A Intron 11 - rs35595 CH 36 20.83 79.17
ML 35 98.57 1.43 ML 35 27.14 72.86
IN 35 84.29 15.71 IN 35 11.43 88.57
CAU 36 84.72 15.28 CAU 36 13.89 86.11
C T C T
SNPi7 I3/-66 T>C Intron 3 - rs4148337 CH 36 40.28 59.72 SNPi17 I11/-48 C>T Intron 11 - rs3765129 CH 36 88.89 11.11
ML 35 44.29 55.71 ML 35 91.43 8.57
IN 35 48.57 51.43 IN 35 97.14 2.86
CAU 35 74.29 25.71 CAU 36 90.28 9.72
A G C T
SNPe2 E6/651 G>A Exon 6 Ser>Ser - CH 36 0.00 100.00 SNPi18 I12/56 C>T Intron 12 - rs17265551 CH 35 98.57 1.43
ML 35 0.00 100.00 ML 35 98.57 1.43
IN 35 2.86 97.14 IN 35 94.29 5.71
CAU 36 0.00 100.00 CAU 36 97.22 2.78
G T C T
SNPi8 I7/31 G>T Intron 7 - rs8187850 CH 35 100.00 0.00 SNPi19 I12/-143 C>T Intron 12 - - CH 31 100.00 0.00
ML 34 100.00 0.00 ML 35 100.00 0.00
IN 35 98.57 1.43 IN 35 98.57 1.43
CAU 36 98.61 1.39 CAU 36 98.61 1.39
A C A G
SNPi9 I7/54 C>A Intron 7 - rs903880 CH 34 1.47 98.53 SNPi20 I12/-85 G>A Intron 12 - rs4148348 CH 36 8.33 91.67
ML 34 2.94 97.06 ML 35 4.29 95.71
IN 35 20.00 80.00 IN 35 5.71 94.29
CAU 36 13.89 86.11 CAU 36 8.33 91.67
C G A G
SNPi10 I7/64 C>G Intron 7 - rs246232 CH 34 61.76 38.24 SNPi21 I12/-37 A>G Intron 12 - rs35604 CH 36 83.33 16.67
ML 34 72.06 27.94 ML 35 85.71 14.29
IN 35 65.71 34.29 IN 35 57.14 42.86
CAU 35 80.00 20.00 CAU 36 79.17 20.83
A G C T
SNPe3 E8/816 G>A Exon 8 Pro>Pro rs2230669 CH 36 2.78 97.22 SNPe7 E13/1684 C>T Exon 13 Leu>Leu rs35605 CH 36 83.33 16.67
ML 35 0.00 100.00 ML 35 85.71 14.29
IN 35 0.00 100.00 IN 35 57.14 42.86
CAU 36 0.00 100.00 CAU 36 80.56 19.44
C T C T
No. SNP ID Region Protein residue dbSNP (rs) Population n Allele frequency (%) No. SNP ID Region Protein residue dbSNP (rs) Population n Allele frequency (%)
SNPe8 E13/1704 C>T Exon 13 Tyr>Tyr rs8187858 CH 36 100.00 0.00 SNPi28 I20/-31 C>T Intron 20 - - CH 36 100.00 0.00
ML 35 100.00 0.00 ML 35 100.00 0.00
IN 35 95.71 4.29 IN 35 100.00 0.00
CAU 36 98.61 1.39 CAU 36 98.61 1.39
C G C T
SNPi22 I13/33 I13/33 Intron 13 - - CH 36 0.00 100.00 SNPe17 E21/2793 C>T Exon 21 Thr>Thr - CH 36 100.00 0.00
ML 35 0.00 100.00 ML 35 100.00 0.00
IN 35 1.43 98.57 IN 35 98.57 1.43
CAU 36 0.00 100.00 CAU 36 100.00 0.00
A G C T
SNPe9 E14/1898 G>A Exon 14 Arg>Gln CH 36 0.00 100.00 SNPi29 I21/26 T>C Intron 21 - rs11075296 CH 36 0.00 100.00
ML 35 0.00 100.00 ML 35 0.00 100.00
IN 35 0.00 100.00 IN 35 1.43 98.57
CAU 36 1.39 98.61 CAU 36 0.00 100.00
C T C T
SNPe10 E16/2001 C>T Exon 16 Ser>Ser rs8187863 CH 36 100.00 0.00 SNPi30 I22/62 T>C Intron 22 - rs3887893 CH 36 58.33 41.67
ML 35 100.00 0.00 ML 35 52.86 47.14
IN 35 100.00 0.00 IN 35 47.14 52.86
CAU 36 98.61 1.39 CAU 36 43.06 56.94
C T C T
SNPe11 E16/2007 C>T Exon 16 Pro>Pro rs2301666 CH 36 98.61 1.39 SNPi31 I22/-43 C>T Intron 22 - - CH 35 91.43 8.57
ML 35 100.00 0.00 ML 35 81.43 18.57
IN 35 100.00 0.00 IN 35 100.00 0.00
CAU 36 100.00 0.00 CAU 36 100.00 0.00
G T A G
SNPe12 E16/2012 G>T Exon 16 Gly>Val - CH 36 100.00 0.00 SNPi32 I24/211 G>A Intron 24 - - CH 36 6.94 93.06
ML 35 100.00 0.00 ML 35 4.29 95.71
IN 35 98.57 1.43 IN 35 1.43 98.57
CAU 36 97.22 2.78 CAU 36 0.00 100.00
A G C T
SNPe13 E17/2168 G>A Exon 17 Arg>Gln rs4148356 CH 36 0.00 100.00 SNPi33 I25/103 C>T Intron 25 - - CH 36 100.00 0.00
ML 35 2.86 97.14 ML 35 100.00 0.00
IN 35 0.00 100.00 IN 35 98.57 1.43
CAU 36 0.00 100.00 CAU 34 100.00 0.00
C T C T
SNPe14 E17/2217 C>T Exon 17 Ser>Ser - CH 36 100.00 0.00 SNPi34 I25/114 C>T Intron 25 - - CH 36 98.61 1.39
ML 35 100.00 0.00 ML 35 100.00 0.00
IN 35 98.57 1.43 IN 35 100.00 0.00
CAU 36 100.00 0.00 CAU 34 100.00 0.00
A G A G
SNPe15 E17/2268 G>A Exon 17 Gly>Gly - CH 36 1.39 98.61 SNPi35 I25/146 G>A Intron 25 - - CH 36 0.00 100.00
ML 35 0.00 100.00 ML 35 1.43 98.57
IN 35 0.00 100.00 IN 35 0.00 100.00
CAU 36 0.00 100.00 CAU 34 0.00 100.00
A G C G
SNPi23 I17/-168 A>G Intron 17 - - CH 31 100.00 0.00 SNPi36 I26/-108 G>C Intron 26 - - CH 36 0.00 100.00
ML 35 97.14 2.86 ML 35 0.00 100.00
IN 29 100.00 0.00 IN 35 2.86 97.14
CAU 32 98.44 1.56 CAU 35 2.86 97.14
C G C T
SNPi24 I18/-30 G>C Intron 18 - rs2074087 CH 36 15.28 84.72 SNPi37 I26/-9 C>T Intron 26 - - CH 36 98.61 1.39
ML 35 12.86 87.14 ML 35 100.00 0.00
IN 35 37.14 62.86 IN 35 100.00 0.00
CAU 36 18.06 81.94 CAU 35 100.00 0.00
A G A G
SNPi25 I18/-27 G>A Intron 18 - rs28363997 CH 36 0.00 100.00 SNPe18 E28/4002 G>A Exon 28 Ser>Ser rs2239330 CH 36 8.33 91.67
ML 35 0.00 100.00 ML 35 7.14 92.86
IN 35 1.43 98.57 IN 35 20.00 80.00
CAU 36 2.78 97.22 CAU 36 37.50 62.50
C T A G
SNPi26 I19/-175 C>T Intron 19 - rs4148369 CH 36 91.67 8.33 SNPi38 I28/-45 G>A Intron 28 - rs212087 CH 36 18.06 81.94
ML 35 91.43 8.57 ML 35 27.14 72.86
IN 35 81.43 18.57 IN 35 38.57 61.43
CAU 36 91.67 8.33 CAU 36 58.33 41.67
C T C T
SNPe16 E20/2651 C>T Exon 20 Thr>Met - CH 36 100.00 0.00 SNPi39 I29/-83 C>T Intron 29 - - CH 36 100.00 0.00
ML 35 98.57 1.43 ML 35 100.00 0.00
IN 35 100.00 0.00 IN 35 97.14 2.86
CAU 36 100.00 0.00 CAU 36 98.61 1.39
C T C G
SNPi27 I20/-59 C>T Intron 20 - - CH 36 100.00 0.00 SNPi40 I30/-51 G>C Intron 30 - - CH 36 0.00 100.00
ML 35 97.14 2.86 ML 35 0.00 100.00
IN 35 100.00 0.00 IN 35 2.86 97.14
CAU 36 100.00 0.00 CAU 35 0.00 100.00

* The numbers of SNPs are defined as SNP(SNP locates the region)(In the certain region, the consequent number of the SNP). For example, SNPu1 means the SNP is located in the untranslated region (UTR) and the first SNP in the UTR.

** SNP ID for these SNPs are defined as (Region)/(position number)(major allele)(minor allele). Region shows whether SNP is in an exon (E) or intron (I). Position number of exonic SNP is the mRNA nucleotide position using the translation start site as position 1. For intronic SNP, the position in the genomic sequence is either upstream (-) of using the 5' boundary of the immediate downstream exon as position -1, or downstream (+) using 3' boundary of the immediate upstream exon as position 1. The same principle is employed to the indel and STR. The position is specific to the first nucleotide in the genomic sequence. (reference mRNA ID:NM_004996.2).

*** CH, ML, IN and CAU represent Chinese, Malay, Indian and Caucasian, respectively.