Figure 2.

Time course of cell yield (cells/muscle) expressed as the ratio of RTA to LTA (mean ± SEM) for normal mice (C57BL/6 and B6129SF, three experiments, ♦), normal mice treated with l-NAME (C57BL/6, three experiments, ▴) and “NOS mutant” mice including mdx and B6129S-Nos1^tm1Plh (NOS-I knockout mice, three experiments, ▪). Satellite cell activation (cell yield ratio of RTA to LTA) in normal mice begins at 0 min and is significantly greater than in mice with NOS inhibition as a result of pharmacological treatment (by l-NAME), a primary gene defect (NOS-I knockout mice), or secondary to dystrophin deficiency (mdx mice).