FIG. 4.

The NS1 protein of influenza virus abolishes the release of proinflammatory cytokines and IFN-α/β by human DCs after infection with influenza virus. Human DCs were infected with influenza virus PR8 or DeltaNS1 or mock infected. Supernatants from infected DCs were tested by ELISA for the release of (A) IFN-α (white bars) and IFN-β (black bars) or (B) TNF-α (black bars) and IL-6 (white bars) at different times after infection. Error bars are for triplicate samples. Data are representative of at least three independent experiments.