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. 2006 Jul;80(13):6295–6304. doi: 10.1128/JVI.02381-05

FIG. 5.

FIG. 5.

The NS1 protein of influenza virus downregulates the expression of specific genes involved in DC maturation. Human DCs were infected with influenza viruses PR8 and DeltaNS1 for 18 h. (A and B) RNAs were isolated from the cells and used to generate cDNAs to perform qRT-PCR for genes involved in DC maturation. Values indicate changes in gene expression in DCs infected by viruses compared to that in uninfected DCs (NI). Error bars represent standard deviations for triplicate samples. Results are representative of three independent experiments with cells from three different donors. (C) At 18 h postinfection, supernatants from infected DCs were analyzed by ELISA for the presence of IP-10 and MIP1β. Error bars are for triplicate samples. Results are representative of three independent experiments with cells from three different donors.