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TABLE 1.

Genotyping analyses reveal that dph3−/− mice are embryonic lethal

Developmental stage No. of progeny
Genotyped as:
Reabsorbedb Total
+/+ +/− −/−a
Adult 54 89 0 143
E12.5 11 27 0 18 56
E11.5 7 7 0 7 21
E10.5 11 20 7* 38
E9.5 20 38 17* 75
E8.5 8 24 8* 40
a

* indicates abnormal, small embryos.

b

Reabsorbed embryos cannot be genotyped because only abnormal placentas fusing with dead embryos were found in these sites. These sites are likely to be the missing homozygous embryos.

HHS Vulnerability Disclosure