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Genotyping analyses reveal that dph3−/− mice are embryonic lethal
| Developmental stage | No. of progeny
|
||||
|---|---|---|---|---|---|
| Genotyped as:
|
Reabsorbedb | Total | |||
| +/+ | +/− | −/−a | |||
| Adult | 54 | 89 | 0 | 143 | |
| E12.5 | 11 | 27 | 0 | 18 | 56 |
| E11.5 | 7 | 7 | 0 | 7 | 21 |
| E10.5 | 11 | 20 | 7* | 38 | |
| E9.5 | 20 | 38 | 17* | 75 | |
| E8.5 | 8 | 24 | 8* | 40 | |
* indicates abnormal, small embryos.
Reabsorbed embryos cannot be genotyped because only abnormal placentas fusing with dead embryos were found in these sites. These sites are likely to be the missing homozygous embryos.
